Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium (mixed strains) has some scientific evidence supporting its use as an adjunct in the management of Celiac Disease, though the evidence is limited and mostly preliminary. Research indicates that individuals with Celiac Disease often have an altered gut microbiota, characterized by a decrease in beneficial Bifidobacterium species. Several small clinical trials and in vitro studies have explored the effects of Bifidobacterium supplementation in people with Celiac Disease, particularly those adhering to a gluten-free diet. Some studies have demonstrated that supplementation with Bifidobacterium infantis, B. longum, or mixed Bifidobacterium strains can help restore a more favorable gut microbial balance, reduce markers of gut inflammation, and improve certain gastrointestinal symptoms. For example, a 2014 randomized controlled trial found that Bifidobacterium infantis supplementation led to a reduction in pro-inflammatory cytokines in children with newly diagnosed Celiac Disease. Another study showed that Bifidobacterium longum supplementation improved gastrointestinal symptoms in children with Celiac Disease on a gluten-free diet. However, the number of studies is small, sample sizes are limited, and the long-term clinical relevance of these findings remains uncertain. There is not yet sufficient evidence to recommend routine use of Bifidobacterium for all patients with Celiac Disease, but the available data provide a rationale for further investigation. Overall, the evidence is promising but still emerging, warranting a modest rating.

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