Bifidobacteria have been investigated for their potential role in supporting individuals with celiac disease, primarily due to their effects on gut health and the modulation of immune responses. Scientific studies have demonstrated that people with celiac disease often display an altered composition of their gut microbiota, with a notable reduction in beneficial bacteria such as Bifidobacteria. Some research suggests that supplementing with Bifidobacteria may help restore a healthier microbial balance, reduce gut inflammation, and improve intestinal barrier function.

Small clinical trials and animal studies have shown that specific strains of Bifidobacteria can decrease pro-inflammatory markers and reduce intestinal permeability in subjects exposed to gliadin, the problematic gluten protein in celiac disease. For example, Bifidobacterium longum and Bifidobacterium infantis have been associated with reduced cytokine production and improved gut barrier integrity in vitro and in vivo.

However, the evidence is still preliminary and mostly based on small-scale studies, with limited large, well-controlled clinical trials in humans. While Bifidobacteria supplementation may offer adjunctive benefits, especially in managing symptoms or restoring microbiota balance, it is not a substitute for a strict gluten-free diet and should not be considered a standalone treatment. Overall, the use of Bifidobacteria in celiac disease is scientifically plausible but not yet strongly validated.