Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E has been investigated for its potential role in the prevention and treatment of cataracts due to its antioxidant properties. Cataracts develop in part because of oxidative damage to the lens of the eye, and antioxidants like vitamin E are thought to neutralize free radicals that contribute to this process. Several observational studies have found that higher dietary intake or blood levels of vitamin E are associated with a reduced risk of cataract formation. For example, some large cohort studies have reported a modest reduction in cataract risk among individuals with higher vitamin E intake. However, randomized controlled trials (RCTs) and meta-analyses have generally failed to demonstrate a significant benefit of vitamin E supplementation in either preventing or slowing the progression of cataracts. Notably, the Age-Related Eye Disease Study (AREDS) and other major trials did not find vitamin E alone, or as part of a supplement formulation, to have a clear protective effect against cataracts. As a result, while there is some scientific interest and a plausible biological mechanism, the clinical evidence supporting vitamin E supplementation for cataract prevention or treatment is weak. Guidelines do not recommend vitamin E supplementation for this purpose, outside of ensuring adequate nutritional intake.

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