Evidence supporting the use of: Vitamin E (alpha-tocopherol)
For the health condition: Cataracts

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Vitamin E (alpha-tocopherol) is an antioxidant that has been hypothesized to play a role in the prevention or slowing of cataract formation due to its ability to neutralize free radicals and reduce oxidative stress, which are believed to contribute to lens opacity. Epidemiological studies have observed that individuals with higher dietary intake or serum levels of vitamin E may have a lower risk of developing cataracts. However, randomized controlled trials (RCTs) and systematic reviews have not consistently demonstrated a clear benefit. For example, large trials such as the Age-Related Eye Disease Study (AREDS) and AREDS2 did not find a significant effect of vitamin E supplementation in preventing cataract development or progression. Similarly, a 2017 Cochrane review concluded that there is no convincing evidence that vitamin E supplementation reduces the risk of cataract or slows its progression in adults. Overall, while the biological rationale exists and population studies suggest a possible association, high-quality clinical evidence does not support the use of vitamin E (alpha-tocopherol) as an effective intervention for cataracts.

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