Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin B2, also known as riboflavin, has a modest scientific basis for its use in the prevention and management of cataracts. Riboflavin is essential for maintaining normal cellular function, growth, and energy production. Several observational studies have linked riboflavin deficiency to an increased risk of developing cataracts, as riboflavin is a cofactor for glutathione reductase, an enzyme important for protecting the lens from oxidative damage. The lens of the eye is particularly vulnerable to oxidative stress, which is a key factor in cataract formation. Some epidemiological studies have found that individuals with higher dietary intake or plasma levels of riboflavin have a lower risk of cataracts. However, controlled clinical trials using riboflavin supplementation to prevent or treat cataracts in humans are limited and have yielded mixed results. The World Health Organization and other health agencies recognize the correction of frank riboflavin deficiency as important for eye health, but there is insufficient evidence to support routine supplementation of riboflavin solely for cataract prevention in well-nourished populations. In summary, while there is some scientific rationale and epidemiological support, the direct clinical evidence for riboflavin supplementation in cataract prevention or treatment is weak, and it is not considered a primary therapeutic agent for this condition.

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