Evidence supporting the use of: Resveratrol
For the health condition: Cataracts

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Resveratrol, a polyphenolic compound found in grapes, berries, and peanuts, has gained attention for its antioxidant properties and potential protective effects against various age-related diseases, including cataracts. The rationale for its use in cataract prevention or treatment is primarily based on laboratory and animal studies that suggest resveratrol can counteract oxidative stress, a key factor in the development of cataracts. Research has demonstrated that resveratrol can reduce lens opacity in animal models and inhibit the formation of advanced glycation end products (AGEs) in the eye lens, which are implicated in cataractogenesis. For example, studies in diabetic rats have shown that resveratrol supplementation can attenuate oxidative damage and delay the onset of cataracts.

However, direct clinical evidence in humans is very limited. There are few, if any, well-designed human clinical trials assessing the efficacy of resveratrol supplements in preventing or treating cataracts. Most of the supportive data come from preclinical research, and while promising, these results do not always translate to human benefit due to differences in metabolism, dosage, and bioavailability. Thus, while there is a scientific rationale and some experimental support for resveratrol’s use in cataract prevention, the overall quality and quantity of evidence remain low. It cannot yet be recommended as a standard therapy for cataracts, but it remains an area of active research.

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