Evidence supporting the use of: Quercetin
For the health condition: Cataracts

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Quercetin, a flavonoid found in many fruits and vegetables, has been investigated for its antioxidant properties, which may be relevant to the prevention or treatment of cataracts. Cataracts develop in part due to oxidative stress-induced damage to the lens proteins, leading to cloudiness and loss of vision. Several preclinical studies (primarily in animal models and in vitro lens cultures) have demonstrated that quercetin can scavenge free radicals, reduce lipid peroxidation, and protect lens epithelial cells from oxidative damage. For instance, studies in diabetic rats have shown that quercetin administration can delay cataract formation, likely via its antioxidant action and possible modulation of the polyol pathway (a contributor to diabetic cataractogenesis).

However, the evidence in humans is very limited. There are no large-scale randomized controlled trials directly evaluating quercetin supplementation for cataract prevention or treatment in people. Some epidemiological studies suggest that diets high in flavonoids (including quercetin) are associated with a lower risk of cataracts, but these do not isolate the effect of quercetin per se. Therefore, while the rationale for using quercetin is scientifically plausible and supported by preclinical research, clinical validation is currently lacking. The evidence supporting its use is modest (rated 2/5), and more robust human studies are needed before quercetin can be recommended as a treatment for cataracts.

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