Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Mixed carotenoids, which include compounds such as beta-carotene, lutein, and zeaxanthin, have been studied for their potential to support eye health and reduce the risk of cataract formation. The biological rationale is that carotenoids possess antioxidant properties, which may help to neutralize free radicals and reduce oxidative stress in the lens of the eye—a key factor implicated in cataract development. Among carotenoids, lutein and zeaxanthin are found in high concentrations in the lens and retina and are thought to filter harmful blue light and protect ocular tissues from light-induced oxidative damage.

Several observational studies have indicated that higher dietary intake or blood levels of certain carotenoids, particularly lutein and zeaxanthin, are associated with a lower risk of developing age-related cataracts. For example, the Age-Related Eye Disease Study (AREDS) and other population studies suggest a possible protective relationship. However, randomized controlled trials (RCTs) have produced mixed results. Some RCTs have not found a significant benefit of carotenoid supplementation in preventing or slowing cataract progression, while others show modest effects.

Overall, while the use of mixed carotenoids for cataracts has a basis in biological plausibility and is supported by some epidemiological evidence, the clinical evidence from high-quality trials is limited and not conclusive. Thus, the strength of evidence is moderate at best, justifying a rating of 2 out of 5.

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Nature's Sunshine Perfect Eyes