Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Catalase is an antioxidant enzyme that breaks down hydrogen peroxide, a reactive oxygen species, into water and oxygen. The rationale for its use in cataracts stems from the role of oxidative stress in the development of lens opacities. Elevated levels of hydrogen peroxide and oxidative damage have been observed in the lenses of patients with cataracts. Preclinical studies, particularly in animal models, have shown that boosting catalase activity in the eye can delay cataract formation. For example, some animal studies have demonstrated that catalase administration or overexpression can protect against lens opacification induced by oxidative stress.

However, direct evidence in humans is limited. Most of the supportive data come from laboratory and animal studies rather than large-scale clinical trials. There are some topical eye drops marketed with catalase (notably for pets) and a few small clinical reports suggest potential benefit, but robust, peer-reviewed human trials are lacking. Thus, while the scientific basis for the use of catalase in cataract prevention or treatment is plausible and supported by preclinical evidence, clinical validation in humans remains insufficient. Overall, the evidence supporting catalase’s use for cataracts rates at about 2 out of 5, reflecting early scientific investigation but a lack of definitive clinical proof.

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