Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Soy unsaponifiables (often combined with avocado unsaponifiables as ASU) have been studied for their potential to support joint health and cartilage integrity, particularly in the context of osteoarthritis. The scientific interest in these compounds arises from their observed effects on cartilage metabolism and inflammation in preclinical and some clinical studies. Several randomized controlled trials and meta-analyses have evaluated ASU’s efficacy, finding modest benefits in symptom relief (pain and stiffness reduction) and a possible slowing of joint space narrowing, particularly in knee and hip osteoarthritis patients. These benefits are believed to result from the inhibition of pro-inflammatory cytokines and stimulation of collagen and proteoglycan synthesis, which are essential for cartilage repair and maintenance. However, the quality of evidence is moderate at best. Most studies are of small to moderate size, with some methodological limitations and potential publication bias. Guidelines from organizations such as the European League Against Rheumatism (EULAR) and the Osteoarthritis Research Society International (OARSI) recognize ASU as a symptomatic slow-acting drug for osteoarthritis (SYSADOA), but do not recommend it as a first-line therapy. The evidence is stronger for symptom relief than for actual regeneration or repair of damaged cartilage. In summary, there is some scientific support for the use of soy unsaponifiables for cartilage-related conditions, but the strength of evidence is limited (rated 2 out of 5).

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