Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Peptides, particularly collagen peptides, have gained attention for their potential role in supporting cartilage health and treating cartilage damage. The scientific justification comes primarily from preclinical studies and a limited number of human clinical trials. Collagen, a major component of cartilage, breaks down in conditions like osteoarthritis. Oral supplementation with hydrolyzed collagen peptides has been shown in some studies to potentially stimulate cartilage matrix synthesis and inhibit cartilage degradation. For example, a few randomized controlled trials (RCTs) have reported modest improvements in joint pain and function in individuals with osteoarthritis after collagen peptide supplementation, though these effects tend to be small and sometimes not clinically significant. The precise mechanisms are not fully understood but may involve the stimulation of chondrocytes (cartilage cells) to produce more extracellular matrix, thereby potentially supporting cartilage repair.

However, the overall quality of evidence is moderate to low. Many studies have significant limitations, such as small sample sizes, short durations, and lack of standardization in peptide formulations. Systematic reviews and meta-analyses suggest there may be a benefit, but they also emphasize the need for higher-quality, longer-term studies. Other types of peptides, such as bioactive short-chain peptides, are under investigation, but robust clinical evidence is lacking. Therefore, while there is some scientific rationale and preliminary evidence supporting the use of peptides for cartilage damage, the evidence base is not strong, and further research is required.

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