Evidence supporting the use of: N-Acetyl Glucosamine
For the health condition: Cartilage Damage
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
N-Acetyl Glucosamine (NAG) is a derivative of glucosamine, a natural compound found in cartilage. It is often used as a dietary supplement for joint health and cartilage support, similar to glucosamine sulfate or glucosamine hydrochloride. The rationale is that glucosamine derivatives serve as building blocks for glycosaminoglycans, which are integral to cartilage structure and function.
Scientific evidence for NAG specifically in the treatment or support of cartilage damage is limited but exists. Most research has focused on glucosamine sulfate or hydrochloride, with mixed results regarding efficacy in osteoarthritis and cartilage repair. A few preclinical studies (in vitro or animal models) suggest that NAG may support cartilage matrix synthesis, reduce inflammation, and protect chondrocytes, but robust human clinical trials are lacking. Some small studies and case reports indicate possible symptomatic relief in joint pain, but these do not establish clear efficacy for cartilage repair or regeneration.
Overall, while there is a plausible biological mechanism and some preliminary evidence, high-quality, large-scale randomized controlled trials in humans are sparse. Thus, the evidence supporting NAG's use for cartilage damage is weak to moderate at best, meriting a rating of 2 out of 5. Clinicians and patients should be aware of the limited nature of the current scientific support.
Other ingredients used for Cartilage Damage
amino acidsanthocyanins
Indian frankincense
bovine gelatin
bromelain
cartilage
chondroitin
collagen
turmeric
curcumin
fish oil
gelatin
ginger
glucosamine
green lipped mussel
green tea
hyaluronic acid
l-proline
methylsulfonylmethane (MSM)
n-acetyl-glucosamine
omega-3 fatty acids
pomegranate
quercetin
resveratrol
silicon
vitamin C
zinc
Animal Tissue
Bone Protein
bovine cartilage / glycosaminoglycan
Chymopapain
Cetylated Fatty Acids
Connective tissue growth factor
Drynaria
fibroblast growth factor
Glycosaminoglycans
Other health conditions supported by N-Acetyl Glucosamine
ArthritisCartilage Damage
Inflammation
Inflammatory Bowel Disorders
Ulcers
Wounds and Sores