Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Methylsulfonylmethane (MSM) is a sulfur-containing compound commonly found in dietary supplements marketed for joint health, including support for cartilage damage. The scientific evidence supporting MSM's use for cartilage damage is limited but present. MSM has been investigated primarily for its anti-inflammatory and analgesic properties rather than direct regenerative effects on cartilage. Several randomized controlled trials have evaluated MSM supplementation in people with osteoarthritis—a condition that includes cartilage degeneration. These studies suggest that MSM may modestly reduce pain and improve joint function compared to placebo, but the improvements are generally small and the quality of evidence is moderate at best.

Experimental studies propose that MSM may exert a protective effect on cartilage by reducing inflammation and oxidative stress, which are factors contributing to cartilage breakdown. However, there is no strong evidence from human studies demonstrating that MSM can repair or regenerate damaged cartilage tissue directly.

Major reviews and clinical guidelines do not strongly endorse MSM as a primary treatment for cartilage damage, although it is sometimes included as part of a broader regimen for symptomatic relief in joint disorders. In summary, MSM's use for cartilage damage has a basis in preliminary scientific research and clinical studies for joint pain, but robust, high-quality evidence for cartilage repair or regeneration is lacking.

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