Evidence supporting the use of: Fibroblast growth factors
For the health condition: Cartilage Damage

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Fibroblast Growth Factors (FGFs) have a scientifically validated role in supporting and treating cartilage damage, primarily based on preclinical and some early clinical research. FGFs, especially FGF-2 (basic FGF), are signaling proteins that play crucial roles in cell proliferation, differentiation, and tissue repair. Numerous animal studies have shown that FGFs can stimulate the proliferation of chondrocytes (cartilage cells) and enhance the synthesis of extracellular matrix components, such as collagen and proteoglycans, which are essential for cartilage health and repair.

In osteoarthritis models, intra-articular (joint) administration of FGF-2 has been demonstrated to promote cartilage regeneration and delay the progression of cartilage degeneration. Moreover, tissue engineering approaches often utilize FGFs to improve the efficacy of cartilage grafts or scaffolds by promoting cell growth and matrix production. Some early-phase clinical trials have explored the use of recombinant FGFs or FGF-mimicking agents for cartilage repair in humans, with promising, though still preliminary, results.

However, it should be noted that while the preclinical evidence is strong, and there is a scientific rationale for using FGFs in cartilage repair, large-scale, long-term clinical trials in humans are still limited. Thus, while scientific evidence supports the use of FGFs for cartilage damage, further research is needed to fully establish their efficacy and safety in routine clinical practice.

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