Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Drynaria (commonly Drynaria fortunei or Drynaria roosii, known as "Gu Sui Bu" in traditional Chinese medicine) has a long history of use in East Asian medicine for bone and joint problems, including trauma and bone fractures. In recent years, there have been several preclinical (animal and cell-based) studies investigating Drynaria’s effects on cartilage repair and protection. These studies have found that extracts of Drynaria rhizome may promote chondrocyte (cartilage cell) proliferation, increase expression of cartilage-specific proteins (such as collagen type II and aggrecan), and reduce expression of inflammatory mediators and cartilage-degrading enzymes (like MMP-13) in models of osteoarthritis and cartilage injury. The primary active compound, naringin, has been studied for its protective effects against cartilage degradation through antioxidant and anti-inflammatory mechanisms.

However, no large-scale, high-quality human clinical trials have been published to confirm efficacy for cartilage damage in humans. Most supporting data are limited to laboratory and animal models. The use of Drynaria in this context is supported by both traditional use for bone and joint healing and emerging but preliminary scientific evidence, though the latter is not yet robust enough for firm clinical recommendations. Thus, the evidence rating is moderate to low, reflecting promising but unconfirmed benefits for cartilage support.

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