Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) commonly prescribed for the management of pain and inflammation associated with musculoskeletal conditions, including those involving cartilage damage such as osteoarthritis. Its primary mechanism of action is the inhibition of cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins—mediators of inflammation and pain. While Diclofenac is effective in alleviating symptoms like pain and swelling, there is limited evidence that it directly supports the healing or regeneration of damaged cartilage. Most clinical studies and guidelines support its use for symptom relief rather than as a disease-modifying therapy.

Scientific validation for Diclofenac’s use in cartilage damage is therefore moderate (rated 2 out of 5), as it addresses the secondary effects (pain and inflammation) rather than the primary pathology (cartilage repair or regeneration). Randomized controlled trials and systematic reviews consistently show short-term benefits in pain reduction and improved function in conditions like osteoarthritis. However, there is also concern that long-term NSAID use, including Diclofenac, might have negative effects on cartilage metabolism, though data are inconclusive. Thus, while Diclofenac is widely used for symptomatic management in cartilage-related conditions, it is not recognized as a therapy that promotes cartilage healing or reversal of damage.

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