Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Connective tissue growth factor (CTGF), also known as CCN2, is a matricellular protein involved in various cellular processes including cell adhesion, migration, proliferation, and differentiation. Scientific research over the past two decades has highlighted CTGF’s significant role in cartilage development and repair. In preclinical studies, CTGF has been shown to promote chondrocyte proliferation and extracellular matrix production, both critical for cartilage integrity and repair. Animal studies have demonstrated that exogenous administration of CTGF can enhance cartilage regeneration in models of cartilage injury and osteoarthritis.

Mechanistically, CTGF acts synergistically with other growth factors such as TGF-β to stimulate the synthesis of collagen type II and aggrecan, major components of cartilage. Some tissue engineering approaches now incorporate CTGF into scaffolds or delivery systems to promote cartilage healing. Nonetheless, while the preclinical data are promising, clinical evidence in humans is still limited, and CTGF is not yet an approved or standard therapy for cartilage damage in clinical practice. Thus, the justification for CTGF’s use in treating cartilage damage is based on a solid body of experimental evidence, but lacks large-scale clinical trials, resulting in a moderate evidence rating.

More about Connective tissue growth factor
More about Cartilage Damage

Other ingredients used for Cartilage Damage

Other health conditions supported by Connective tissue growth factor

Products containing Connective tissue growth factor