Evidence supporting the use of: Vitamin D3
For the health condition: Cardiovascular Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin D3 (cholecalciferol) has been investigated for its potential role in supporting cardiovascular health due to the widespread presence of vitamin D receptors in the heart and vascular tissues, as well as epidemiological associations between low serum vitamin D levels and increased cardiovascular risk. Research has shown that vitamin D deficiency is linked to hypertension, coronary artery disease, heart failure, and increased risk of cardiovascular events. The proposed mechanisms involve vitamin D’s influence on inflammation, endothelial function, renin-angiotensin-aldosterone system regulation, and glucose metabolism—all factors relevant to cardiovascular health.

However, while observational studies suggest a correlation between low vitamin D status and cardiovascular disease (CVD), randomized controlled trials (RCTs) and meta-analyses of vitamin D supplementation have produced mixed results. Large-scale studies such as the VITAL trial (2019) did not find a significant reduction in major cardiovascular events among those supplementing with vitamin D3 compared to placebo. Some smaller studies and meta-analyses suggest modest benefits in specific populations (e.g., those who are deficient in vitamin D at baseline), but overall, the evidence for vitamin D3 supplementation as a treatment or preventive measure for CVD is limited and inconsistent.

Current guidelines do not recommend vitamin D supplementation specifically for cardiovascular disease prevention or treatment unless there is a documented deficiency. Therefore, while there is a scientific rationale and ongoing research, strong clinical evidence supporting vitamin D3 as a cardiovascular therapy is lacking at this time.

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