Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Vitamin E (mixed tocopherols) has been investigated for its potential role in supporting or treating cardiovascular disease (CVD) due to its antioxidant properties, which could theoretically reduce oxidative stress implicated in atherosclerosis. Early observational studies suggested that higher dietary intake or blood levels of vitamin E were associated with lower risk of coronary heart disease. However, large randomized controlled trials, such as the HOPE and Women's Health Study, have failed to demonstrate a significant benefit of vitamin E supplementation in reducing cardiovascular events or mortality. Some studies have even raised concerns about potential harm, such as increased risk of hemorrhagic stroke at high doses.

Current scientific consensus is that vitamin E supplementation does not provide cardiovascular benefit in the general population and is not recommended for prevention or treatment of CVD. The American Heart Association and similar bodies do not endorse vitamin E supplements for cardiovascular protection. However, vitamin E remains of scientific interest, particularly in populations with specific deficiencies or certain genetic backgrounds, but robust clinical validation is lacking. Overall, the evidence supporting vitamin E’s use in cardiovascular disease is limited and inconsistent, meriting a low rating for scientific support.

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