Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Softgels are a dosage form, not an active ingredient, but many nutraceuticals and pharmaceuticals delivered in softgel form are used for cardiovascular health. Notably, omega-3 fatty acids (such as EPA and DHA from fish oil) are commonly encapsulated in softgels to improve stability, palatability, and absorption. There is scientific evidence supporting the use of omega-3 fatty acids for reducing triglyceride levels and, to a lesser extent, for reducing cardiovascular events. Meta-analyses and large-scale randomized controlled trials have shown that prescription-strength omega-3 formulations can lower triglycerides and may modestly reduce the risk of major cardiovascular events, particularly in high-risk populations (Bhatt et al., NEJM 2019). However, results are mixed and benefits appear more consistent with higher-dose, purified forms rather than over-the-counter supplements. Softgel encapsulation itself does not confer cardiovascular benefits, but is a preferred delivery method for lipid-based actives due to its ability to prevent oxidation and mask taste. Overall, the scientific support is primarily for the active ingredients (such as omega-3s) commonly delivered in softgel form, not for softgels per se.

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