Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Schisandrins, the active lignans found in Schisandra chinensis, have been studied for their potential cardioprotective effects. While Schisandra has a long history of use in Traditional Chinese Medicine (TCM), its application for cardiovascular disease (CVD) is increasingly supported by preclinical scientific studies rather than just tradition. Experimental research, primarily in animal models and in vitro settings, has shown that schisandrins may exert antioxidant, anti-inflammatory, and anti-apoptotic effects on cardiac tissue. For example, schisandrin B has been reported to reduce myocardial ischemia-reperfusion injury by attenuating oxidative stress and mitochondrial dysfunction. Some studies also suggest schisandrins can improve lipid metabolism, reduce cardiac fibrosis, and inhibit hypertrophy, all of which are relevant to CVD pathogenesis.

However, clinical evidence in humans is limited. Most supporting data come from laboratory or animal studies rather than large-scale human clinical trials. As such, while there is a scientific rationale and preliminary evidence for schisandrins’ potential benefits in cardiovascular health, the current level of evidence is modest and insufficient for strong clinical recommendations. Further human studies are needed to validate these effects, determine appropriate dosages, and clarify safety profiles in the context of cardiovascular disease.

More about Schisandrins
More about Cardiovascular Disease

Other ingredients used for Cardiovascular Disease

Other health conditions supported by Schisandrins

Products containing Schisandrins