Evidence supporting the use of: Rutin
For the health condition: Cardiovascular Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Rutin, a flavonoid glycoside found in various plants such as buckwheat, citrus fruits, and apples, has been studied for its potential cardiovascular benefits. Scientific interest in rutin stems from its antioxidant, anti-inflammatory, and vasoprotective properties, which are relevant to cardiovascular disease (CVD) prevention and management. Preclinical studies (in vitro and animal models) suggest that rutin can help protect blood vessels, reduce blood pressure, inhibit platelet aggregation, and decrease oxidative stress—factors involved in the pathogenesis of atherosclerosis and other cardiovascular conditions. Some small clinical trials have reported improvements in capillary fragility, peripheral circulation, and symptoms of chronic venous insufficiency with rutin supplementation.

However, large-scale, high-quality human studies specifically addressing major cardiovascular endpoints (such as myocardial infarction, stroke, or cardiovascular mortality) are lacking. Most clinical evidence relates to improvements in symptoms like leg swelling or varicose veins rather than hard cardiovascular outcomes. As such, while the scientific rationale for rutin’s use is plausible and supported by mechanistic data and some clinical observations, robust evidence in humans for the prevention or treatment of cardiovascular disease remains limited. More research is needed to confirm its efficacy and safety for this indication. Therefore, the scientific evidence supporting rutin’s use in cardiovascular disease is promising but currently rated as weak to moderate.

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