Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Linoleic acid (LA) is an omega-6 polyunsaturated fatty acid found abundantly in vegetable oils, nuts, and seeds. Its use in supporting or treating cardiovascular disease (CVD) is primarily justified by scientific evidence rather than tradition. Numerous epidemiological and interventional studies have investigated the effects of dietary linoleic acid on cardiovascular health. The majority of observational studies suggest that higher dietary intake of linoleic acid is associated with reduced risk of coronary heart disease (CHD). Meta-analyses of randomized controlled trials have found that replacing saturated fat with polyunsaturated fats, especially LA, leads to modest reductions in total and LDL cholesterol, both established risk factors for CVD. The American Heart Association and other major health organizations recommend increasing polyunsaturated fat intake, including LA, as part of a heart-healthy diet. However, the evidence is not unequivocal. Some concerns have been raised about potential pro-inflammatory effects of excessive omega-6 intake, but current consensus holds that typical dietary levels of LA do not increase inflammation and are likely beneficial for CVD prevention. Overall, the support for LA in cardiovascular health is moderate, stemming from both mechanistic studies and large-scale population data, but not reaching the highest level of evidence due to some inconsistencies and lack of long-term randomized controlled trials focusing solely on LA.

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Products containing linoleic acid (LA)

Nature's Sunshine Evening Primrose Oil