Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lactobacillus reuteri has been explored for its potential cardiovascular benefits, primarily through scientific rather than traditional channels. The main mechanisms proposed relate to its effects on lipid metabolism, inflammation, and modulation of the gut microbiota. Several small clinical trials and animal studies have investigated L. reuteri supplementation, particularly the strain L. reuteri NCIMB 30242, in relation to cholesterol levels. Some studies have reported modest reductions in total cholesterol and LDL-cholesterol after supplementation, thought to be mediated by enhanced bile salt hydrolase activity and altered cholesterol absorption in the gut. Additionally, there is emerging evidence that L. reuteri may exert anti-inflammatory effects, which could theoretically benefit cardiovascular health by reducing systemic inflammation, a known risk factor for atherosclerosis.

However, the overall evidence base remains limited. Most human studies have been small, short-term, and sometimes industry-sponsored. The observed reductions in cholesterol are typically modest (e.g., 8-12% LDL-C reduction) and the impact on clinical cardiovascular endpoints (such as heart attacks or strokes) has not been established. There is currently insufficient high-quality evidence to recommend L. reuteri as a primary or adjunctive therapy for cardiovascular disease, but research is ongoing. In summary, while the rationale is biologically plausible and there are some early supportive findings, the strength of evidence is limited, warranting a rating of 2 out of 5.

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