Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eriocitrin is a flavonoid glycoside predominantly found in lemons and other citrus fruits. Its use in supporting or treating cardiovascular disease is based on emerging scientific evidence, primarily from preclinical (animal and cell) studies and a limited number of small human trials.

Research indicates that eriocitrin exhibits antioxidant and anti-inflammatory properties, both of which are relevant to cardiovascular health. Specifically, studies have shown that eriocitrin can reduce oxidative stress and inhibit LDL cholesterol oxidation—a key process in the development of atherosclerosis. In animal models, supplementation with eriocitrin has resulted in lower blood lipid levels (including total cholesterol and triglycerides) and improved markers of endothelial function.

Some early-phase human studies have investigated eriocitrin-rich lemon extracts and reported modest improvements in blood lipid profiles and reductions in markers of oxidative stress. For example, a 2022 randomized controlled trial using lemon extract standardized for eriocitrin observed reduced cholesterol and improved antioxidant status in mildly hypercholesterolemic subjects. However, these studies are generally small, short-term, and often use eriocitrin as part of a complex mixture rather than as an isolated compound.

Overall, while there is some scientific rationale and preliminary evidence supporting eriocitrin for cardiovascular health, robust clinical trials are lacking. Thus, the evidence is rated as low to moderate (2/5), and its use should be considered experimental rather than established.

More about Eriocitrin
More about Cardiovascular Disease

Other ingredients used for Cardiovascular Disease

Other health conditions supported by Eriocitrin

Products containing Eriocitrin