Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Arginine is an amino acid that serves as a precursor to nitric oxide (NO), a molecule that plays a key role in vasodilation and vascular health. Because of its biological function, arginine supplementation has been investigated for potential benefits in cardiovascular disease (CVD), including hypertension, angina, and peripheral arterial disease. Some clinical studies have shown that arginine supplementation can improve endothelial function and enhance blood flow by increasing nitric oxide production. However, the evidence is mixed and somewhat controversial. While early small-scale studies and short-term interventions suggested possible improvements in blood pressure and vascular reactivity, larger and longer-term clinical trials have not consistently demonstrated significant cardiovascular benefit. In fact, some research has raised concerns about safety, particularly following myocardial infarction, where arginine supplementation was associated with increased mortality in one trial. Major cardiovascular organizations do not currently recommend arginine supplementation as a treatment for CVD. In summary, while there is a clear biological rationale and some scientific investigation, the overall quality and consistency of evidence supporting arginine's use for cardiovascular disease is limited, and its use should be approached with caution.

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