Apocynum venetum, also known as Luobuma, is a traditional Chinese medicinal herb that has garnered scientific interest for its potential cardiovascular benefits. Historically, it has been used in traditional medicine systems, particularly in China, for indications such as hypertension and heart palpitations. Modern research has begun to validate some of these traditional uses. Preclinical studies indicate that extracts of Apocynum venetum leaves exhibit antihypertensive properties, likely mediated through vasodilation, antioxidant activity, and modulation of the renin-angiotensin system. For example, studies in spontaneously hypertensive rats have demonstrated significant reductions in blood pressure following administration of the plant's leaf extract, with suggested mechanisms including increased nitric oxide production and inhibition of oxidative stress.

Additionally, some human studies—though generally small and of limited duration—have shown modest reductions in blood pressure among patients with mild hypertension. The plant also contains flavonoids such as hyperoside and isoquercitrin, which are believed to contribute to its cardiovascular effects by improving endothelial function and reducing oxidative damage. However, large-scale, high-quality clinical trials in humans are lacking, and most of the evidence is preclinical or from small pilot studies. Therefore, while there is some scientific basis for the use of Apocynum venetum in supporting cardiovascular health, especially blood pressure regulation, the evidence is not yet robust enough to recommend it as a primary therapy.