Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Antioxidants have been studied extensively in the context of cardiovascular disease (CVD) due to their ability to neutralize free radicals and reduce oxidative stress, which is implicated in the pathogenesis of atherosclerosis and other cardiovascular conditions. Epidemiological studies have shown that diets rich in antioxidant-containing foods (such as fruits and vegetables) are associated with a reduced risk of CVD. However, large-scale randomized controlled trials using antioxidant supplements—most commonly vitamin E, vitamin C, and beta-carotene—have generally failed to demonstrate a significant benefit in reducing cardiovascular events or mortality in the general population.

Some studies have even suggested potential harm with high-dose supplementation, especially with beta-carotene in smokers. The discrepancy between observational studies and intervention trials may be due to the complex interactions of antioxidants in whole foods versus isolated supplements, or confounding lifestyle factors. Guidelines from major cardiovascular societies do not recommend routine antioxidant supplementation for the prevention or treatment of cardiovascular disease.

In summary, while there is biological plausibility and some observational support for the role of antioxidants in cardiovascular health, the evidence from high-quality clinical trials for using unspecified antioxidant supplements to treat or prevent CVD is considered weak (rated 2 out of 5), and supplementation is not routinely recommended.

More about Antioxidant (unspecified)
More about Cardiovascular Disease

Other ingredients used for Cardiovascular Disease

Other health conditions supported by Antioxidant (unspecified)

Products containing Antioxidant (unspecified)