Gnaphalium, commonly known as cudweed, has a long history of use in traditional herbal medicine across various cultures. In particular, species such as Gnaphalium polycephalum and Gnaphalium uliginosum have been utilized in folk remedies for their purported anti-inflammatory and wound-healing properties. Historical accounts and ethnobotanical surveys indicate that poultices and topical applications made from Gnaphalium leaves or extracts were applied to skin eruptions, boils, and carbuncles to promote healing and reduce inflammation. However, these uses are primarily based on tradition and anecdotal reports rather than rigorous scientific studies.

A search of the biomedical literature reveals scant direct evidence supporting the efficacy of Gnaphalium for carbuncles specifically. While some phytochemical studies have identified the presence of flavonoids, terpenoids, and other bioactive compounds with general antimicrobial or anti-inflammatory activities, no clinical trials or robust preclinical studies have evaluated its effectiveness in treating carbuncles (which are deep, pus-filled skin infections). Therefore, the use of Gnaphalium for carbuncles remains a traditional practice, with evidence limited to historical and ethnobotanical sources rather than validated scientific research.