Citrus fruits, particularly their peels and pulps, are rich sources of flavonoids such as hesperidin and rutin. There is scientific evidence that these flavonoids play a role in supporting capillary strength and reducing capillary fragility. Several studies, especially on hesperidin (often in combination with diosmin), have shown benefits in improving microcirculation and decreasing capillary permeability, which can help prevent or reduce symptoms like easy bruising or small vessel bleeding. These compounds are thought to work by enhancing the integrity of capillary walls, reducing inflammation, and improving venous tone.

Clinical trials have particularly focused on the use of citrus-derived flavonoids for chronic venous insufficiency, hemorrhoids, and related vascular conditions. For example, a systematic review published in Phytotherapy Research (2015) reported that hesperidin, alone or with diosmin, can reduce symptoms of capillary fragility and improve vascular health. Additionally, older pharmacological research supports the use of citrus flavonoids to decrease capillary permeability and strengthen blood vessel walls.

However, while the evidence is promising and based on both laboratory and clinical studies, much of it pertains to standardized extracts or specific flavonoids rather than whole citrus fruit consumption. There is a moderate level of scientific validation, but more high-quality, large-scale clinical trials would be valuable to confirm the effectiveness and optimal dosing for capillary weakness.