Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Anthocyanosides—the active flavonoid compounds in bilberry (Vaccinium myrtillus) and other berries—are used to support or treat capillary weakness primarily based on scientific evidence, though traditional use also exists. Scientific studies suggest that anthocyanosides strengthen capillary walls by stabilizing collagen fibers and promoting the synthesis of connective tissue. They are known for their antioxidant activity, which reduces oxidative damage to capillary endothelium. Clinical studies, particularly from European research in the late 20th century, have shown that anthocyanoside extracts can help reduce capillary fragility and permeability in conditions such as chronic venous insufficiency, edema, and diabetic retinopathy. For example, a double-blind study (Cesarone et al., 2002) demonstrated improvement in microcirculation and capillary resistance with anthocyanoside supplementation. However, while the evidence is suggestive and mechanistically plausible, the overall quality and quantity of clinical trials are moderate, often with small sample sizes and methodological limitations. Systematic reviews acknowledge potential benefits but call for larger, high-quality studies to confirm efficacy. Thus, the evidence for anthocyanosides in supporting capillary strength is promising—mainly from European phytomedicine literature—but not conclusive, meriting a moderate rating.

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