Evidence supporting the use of: Nitrate (unspecified)
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Nitrates, commonly found in foods like leafy green vegetables and beets, are scientifically validated for their effects on the vascular system, including capillaries. The primary mechanism involves the conversion of dietary nitrates into nitric oxide (NO) in the body. Nitric oxide is a potent vasodilator, meaning it relaxes the smooth muscle cells within blood vessels, which leads to improved blood flow, reduced blood pressure, and enhanced oxygen delivery to tissues. Numerous studies have demonstrated that nitrate supplementation improves endothelial function, increases capillary blood flow, and can support overall microcirculatory health. While much of the clinical research has focused on cardiovascular outcomes, improved capillary function is considered a key component of these benefits. For example, a 2013 study in the journal "Hypertension" showed that dietary nitrate intake led to significant improvements in microvascular (capillary) function in humans. Another study published in "Circulation Research" in 2015 highlighted the role of nitrates in enhancing tissue perfusion, especially under conditions of hypoxia or exercise. Overall, while "nitrate (unspecified)" is a broad term, nitrate compounds as a group have a strong scientific basis for supporting capillary health and function. There is, however, less evidence for their use in treating specific capillary-related diseases, but the general vascular and microvascular benefits are well supported by current scientific literature.

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