Evidence supporting the use of: L-arginine
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

L-arginine is an amino acid that serves as a precursor for nitric oxide (NO) synthesis, a molecule essential for the regulation of vascular tone and blood flow. The capillaries are the smallest blood vessels in the body and play a critical role in microvascular circulation. Scientific studies have shown that L-arginine supplementation can increase nitric oxide production, which leads to vasodilation and improved endothelial function. These effects are relevant to the health of capillaries and the broader vascular system, including benefits for blood flow and possibly wound healing.

Clinical research has primarily focused on populations with cardiovascular risk factors, such as hypertension, peripheral artery disease, or diabetes, where endothelial dysfunction is common. While there is moderate evidence that L-arginine can improve endothelial function and microcirculation in these groups, results are mixed, and large-scale studies are limited. Some studies suggest short-term improvements in microvascular blood flow, but long-term benefits and direct effects specifically on capillary structure or function remain less clear.

In summary, the use of L-arginine to support capillary health is scientifically plausible and supported by moderate evidence relating to vascular function, but more robust, targeted research is needed to confirm direct benefits for capillary integrity and function in healthy individuals.

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