Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hesperetin is a flavonoid aglycone derived from hesperidin, found predominantly in citrus fruits. Its use to support capillary health and the vascular system has some scientific basis, though the evidence is limited and mostly preclinical. Several in vitro and animal studies suggest hesperetin possesses antioxidant, anti-inflammatory, and vasoprotective properties. These attributes theoretically benefit capillary integrity by reducing oxidative stress and inflammation, both of which can compromise capillary structure and function. Some studies indicate hesperetin can improve endothelial function, inhibit capillary permeability, and reduce microvascular leakage, which are relevant to capillary health.

However, there is a relative paucity of high-quality clinical trials in humans specifically demonstrating hesperetin’s efficacy for capillary support. Most available human research focuses on broader cardiovascular outcomes, and often uses hesperidin (the glycosylated form) rather than hesperetin. Nonetheless, hesperidin-containing formulations have been used in Europe for chronic venous insufficiency and hemorrhoidal disease, indirectly supporting the rationale for hesperetin’s vascular benefits. Overall, the scientific evidence is promising but not robust, meriting a moderate evidence rating for capillary support.

More about Hesperitin
More about Capillaries

Other ingredients that support Capillaries

alpha-glycosyl isoquercitrin
anthocyanins
apple
astragalus
bilberry
black currant
blueberry
butcher's broom
Chinese salvia root
chokeberry
citrus bioflavonoids
fish oil
flavonols
garlic bulb
ginkgo biloba
gotu kola
grape
onion
hawthorn
hesperidin
horse chestnut
Japanese sophora
L-arginine
Nattokinase
orange
phenolic compounds
pine bark
quercetin
rutin
vitamin B
vitamin C
vitamin E
vitamin K
Water
capsicum
lingzhi
Yarrow
Yarrow
prickly ash
sodium salt
terpene lactones
polyphenols
purslane
shepherd's purse
herbal blend (proprietary)
cayenne pepper
ashitaba
asiaticoside
Aronia melanocarpa
Aescin
anthocyanidins
anthocyanosides
apocynin
astragalin
Baikal Skullcap
baicalein
benfotiamine
berry
bioflavonoids
coumarin
Centella triterpenes
cyanidin
Citrus
Centella asiatica
coca
capers
cypress
cranesbill
Collinsonia
Diosmin
danshen
delphinidin
dextran
diosmetin
epicatechin
Erigeron
eicosapentaenoic acid
escin
fruit
flavonoids
fatty acids
flavanones
Fagopyrum
flavoglycosides
flavans
flavonones
flavanols
flavones
Gypenoside
ginkgolides
ginkgo flavone glycoside
Ginkgoside
ginkgoheteroside
Hyperoside
Immortelle
linden
Ligustrazin
leucoanthocyanidins
Ligusticum
Mineral ascorbate
Oligomeric proanthocyanidins
Phenylpropanoids
pagoda tree
procyanidol
procyanidin
Pentacyclic triterpenoids
Phosphate ascorbate
Polydatin
proanthocyanidins
Periwinkle
punicalagins
Pycnogenol
polymethoxylated flavones
rue
Ruscus
Ruscogenins
Rutosides
Salmon Oil
Salvianolic acid
Scotch Broom
Sweet Clover
Stone Root
Terpenoids
Taxifolin
Troxerutin
Vincamine
Vitexin
Witch Hazel
Xantinol Nicotinate
Yumberry

Other body systems supported by Hesperitin

Arteries
Blood
Brain
Capillaries
Circulatory System
Heart
Immune System
Intestinal System

Products containing Hesperitin

We currently have no products on Caring Sunshine that contain this ingredient.