Hesperidin methyl chalcone is a modified form of hesperidin, a flavonoid commonly found in citrus fruits. Its primary use in supporting the capillaries and the vascular system is based on both scientific research and its inclusion in various formulations for chronic venous insufficiency and related conditions. Several clinical studies and reviews—primarily from Europe—have reported that hesperidin methyl chalcone, often in combination with other flavonoids like diosmin, can improve capillary resistance and reduce symptoms such as capillary fragility, edema, and venous insufficiency. Its mechanism of action is believed to involve antioxidant effects, strengthening of capillary walls, and reduction of vascular permeability.

The European Medicines Agency and other regulatory bodies recognize hesperidin methyl chalcone as a vasoprotective agent. However, the quality of evidence varies, with most studies being small, short-term, or involving combination products, which makes it difficult to attribute benefits solely to hesperidin methyl chalcone. Nonetheless, the consistency of findings regarding improved capillary function and reduced symptoms associated with capillary fragility provides moderate scientific support for its use in this context.

In summary, while hesperidin methyl chalcone is not universally endorsed by all health authorities, there is moderate scientific evidence supporting its benefit for capillary health, particularly in conditions involving increased capillary fragility or chronic venous disorders.