Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Gypenoside, a group of saponin compounds extracted primarily from the plant Gynostemma pentaphyllum (Jiaogulan), has been traditionally used in East Asian herbal medicine. In recent decades, scientific research has begun to explore its pharmacological effects, including potential benefits for the vascular system, specifically the capillaries. Some in vitro and animal studies suggest that gypenosides may exert protective effects on endothelial cells, which line the capillaries, by reducing oxidative stress, inflammation, and by improving microcirculatory function. For example, research has shown that gypenosides can attenuate endothelial dysfunction and may enhance capillary integrity under certain conditions. However, clinical trials in humans directly demonstrating improved capillary health or function as a result of gypenoside supplementation are very limited and generally of low quality.

While there is mechanistic and preclinical evidence to suggest a supportive role for gypenosides in vascular health, including capillaries, the evidence remains preliminary. Most claims are extrapolated from animal or cell models, and robust human data are lacking. Therefore, the scientific support for using gypenosides specifically to support the capillaries is modest at best.

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