Ginkgoheteroside is one of the main flavonoid glycosides found in Ginkgo biloba leaves. Ginkgo biloba extract, standardized to contain defined amounts of flavonoid glycosides (including ginkgoheteroside), has been studied for its effects on vascular health, particularly microcirculation and capillary integrity. Several clinical trials and reviews support the use of standardized Ginkgo biloba extracts for improving peripheral circulation, reducing capillary fragility, and enhancing blood flow, especially in elderly subjects and those with circulatory disorders.

The proposed mechanisms include antioxidant effects, inhibition of platelet-activating factor, and stabilization of capillary walls. The evidence base includes randomized controlled trials and meta-analyses, such as those summarized in Cochrane reviews and pharmacological research literature. However, it is important to note that most research examines the whole standardized extract (which includes ginkgoheteroside among other components), and not isolated ginkgoheteroside. Thus, while there is scientific justification for the role of Ginkgo biloba extracts in supporting capillary health, direct evidence for isolated ginkgoheteroside is limited.

Overall, the use of ginkgoheteroside as part of Ginkgo biloba extracts to support capillary function is supported by moderate scientific evidence, though more research is needed on the isolated compound.