Evidence supporting the use of: Flavones
For the body system: Capillaries
Synopsis
Source of validity: Scientific
Rating (out of 5): 3
Flavones, a class of plant-derived polyphenolic compounds found in foods such as parsley, celery, and chamomile, have demonstrated some scientific support for their role in supporting capillary health. Flavones, particularly diosmin and hesperidin (often referred to as "citrus flavonoids"), have been studied for their vascular protective effects. Research indicates that these compounds can strengthen capillary walls, reduce capillary permeability, and improve microcirculation. For example, clinical studies on patients with chronic venous insufficiency and related capillary fragility have shown that flavone-rich extracts can decrease edema, reduce symptoms such as leg heaviness, and decrease bruising by stabilizing capillary membranes and inhibiting inflammatory mediators. The proposed mechanisms include antioxidant activity, inhibition of enzymes that degrade capillary integrity (such as hyaluronidase), and modulation of vascular tone. However, most studies involve specific flavones (like diosmin or hesperidin) rather than the entire class, and some positive results come from combination products, making it difficult to assign effects solely to flavones. The overall evidence is moderate, with several randomized controlled trials and mechanistic studies supporting their benefit, but further research is needed to determine the efficacy and optimal dosing of flavones for capillary health in the general population.
Other ingredients that support Capillaries
alpha-glycosyl isoquercitrinanthocyanins
apple
astragalus
bilberry
black currant
blueberry
butcher's broom
Chinese salvia root
chokeberry
citrus bioflavonoids
fish oil
flavonols
garlic bulb
ginkgo biloba
gotu kola
grape
onion
hawthorn
hesperidin
horse chestnut
Japanese sophora
L-arginine
Nattokinase
orange
phenolic compounds
pine bark
quercetin
rutin
vitamin B
vitamin C
vitamin E
vitamin K
Water
capsicum
lingzhi
Yarrow
Yarrow
prickly ash
sodium salt
terpene lactones
polyphenols
purslane
shepherd's purse
herbal blend (proprietary)
cayenne pepper
ashitaba
asiaticoside
Aronia melanocarpa
Aescin
anthocyanidins
anthocyanosides
apocynin
astragalin
Baikal Skullcap
baicalein
benfotiamine
berry
bioflavonoids
coumarin
Centella triterpenes
cyanidin
Citrus
Centella asiatica
coca
capers
cypress
cranesbill
Collinsonia
Diosmin
danshen
delphinidin
dextran
diosmetin
epicatechin
Erigeron
eicosapentaenoic acid
escin
fruit
flavonoids
fatty acids
flavanones
Fagopyrum
flavoglycosides
flavans
flavonones
flavanols
flavones
Gypenoside
ginkgolides
ginkgo flavone glycoside
Ginkgoside
ginkgoheteroside
Hyperoside
Immortelle
linden
Ligustrazin
leucoanthocyanidins
Ligusticum
Mineral ascorbate
Oligomeric proanthocyanidins
Phenylpropanoids
pagoda tree
procyanidol
procyanidin
Pentacyclic triterpenoids
Phosphate ascorbate
Polydatin
proanthocyanidins
Periwinkle
punicalagins
Pycnogenol
polymethoxylated flavones
rue
Ruscus
Ruscogenins
Rutosides
Salmon Oil
Salvianolic acid
Scotch Broom
Sweet Clover
Stone Root
Terpenoids
Taxifolin
Troxerutin
Vincamine
Vitexin
Witch Hazel
Xantinol Nicotinate
Yumberry
