Flavoglycosides are a subclass of flavonoids, which are polyphenolic compounds found abundantly in various plants. One of the most studied flavoglycosides for capillary support is diosmin, often sourced from citrus fruits. Scientific research has demonstrated that flavoglycosides possess vasoprotective properties, particularly through mechanisms that enhance capillary resistance, reduce capillary permeability, and improve venous tone. Several clinical studies and meta-analyses have shown that flavoglycosides, especially as micronized purified flavonoid fraction (MPFF, commonly containing diosmin and hesperidin), can reduce symptoms of chronic venous insufficiency, such as leg swelling and varicose veins, by strengthening capillary walls and reducing inflammation.

The European Medicines Agency (EMA) and other regulatory bodies recognize the use of certain flavoglycosides for the treatment of chronic venous disorders. Mechanistically, these compounds are thought to inhibit inflammatory mediators, protect endothelial cells, and stabilize capillary membranes, thereby reducing leakage and fragility. While most evidence centers on diosmin and hesperidin, other flavoglycosides like rutin have also shown benefits in increasing capillary resistance and reducing microvascular bleeding in clinical settings.

In summary, there is substantial scientific evidence supporting the use of specific flavoglycosides for capillary health, underpinned by both laboratory and clinical research.