Evidence supporting the use of: Flavanones (various)
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Flavanones, a subclass of flavonoids found abundantly in citrus fruits (such as hesperidin, naringin, and eriocitrin), have been studied for their beneficial effects on the vascular system, including capillary health. Several clinical and preclinical studies support their use in strengthening capillaries and improving microcirculation. Hesperidin, in particular, is often included in formulations for chronic venous insufficiency and capillary fragility. Evidence suggests that flavanones exert protective effects by reducing capillary permeability, strengthening capillary walls, and exhibiting anti-inflammatory and antioxidant properties. These actions help to prevent microvascular leakage and support overall capillary integrity.

Randomized controlled trials with hesperidin and related compounds indicate improvements in symptoms such as leg swelling, heaviness, and visible capillary fragility. Reviews published in journals such as Phytotherapy Research and the Journal of Clinical Medicine summarize both mechanistic and clinical evidence for these effects. Additionally, the European Medicines Agency has recognized certain flavanone-rich extracts as traditional herbal medicines for the relief of symptoms related to venous insufficiency.

While more high-quality clinical research is warranted for some specific flavanones, the current body of evidence, both experimental and clinical, justifies their use to support capillary health.

More about Flavanones (various)
More about Capillaries

Other ingredients that support Capillaries

alpha-glycosyl isoquercitrin
anthocyanins
apple
astragalus
bilberry
black currant
blueberry
butcher's broom
Chinese salvia root
chokeberry
citrus bioflavonoids
fish oil
flavonols
garlic bulb
ginkgo biloba
gotu kola
grape
onion
hawthorn
hesperidin
horse chestnut
Japanese sophora
L-arginine
nattokinase
orange
phenolic compounds
pine bark
quercetin
rutin
vitamin B
vitamin C
vitamin E
vitamin K
water
capsicum
lingzhi
yarrow
yarrow
prickly ash
sodium salt
terpene lactones
polyphenols
purslane
shepherd's purse
herbal blend (proprietary)
cayenne pepper
ashitaba
Asiaticoside
Aronia melanocarpa
Aescin
anthocyanidins
anthocyanosides
Apocynin
Astragalin
Baikal Skullcap
Baicalein
Benfotiamine
berry
Bioflavonoids
Coumarin
Centella triterpenes
Cyanidin
Citrus
Centella asiatica
Coca
Capers
cypress
Cranesbill
Collinsonia
Diosmin
Danshen
Delphinidin
Dextran
Diosmetin
epicatechin
Erigeron
Eicosapentaenoic Acid
Escin
Fruit
Flavonoids
Fatty acids
Flavanones
Fagopyrum
Flavoglycosides
Flavans
Flavonones
Flavanols
Flavones
Gypenoside
Ginkgolides
Ginkgo Flavone Glycoside
Ginkgoside
Ginkgoheteroside
Hyperoside
Immortelle
Linden
Ligustrazin
Leucoanthocyanidins
Ligusticum
Mineral ascorbate
Oligomeric proanthocyanidins
Phenylpropanoids
Pagoda Tree
Procyanidol
Procyanidin
Pentacyclic triterpenoids
Phosphate ascorbate
Polydatin
Proanthocyanidins
Periwinkle
Punicalagins
Pycnogenol
Polymethoxylated flavones
Rue
Ruscus
Ruscogenins
Rutosides
Salmon Oil
Salvianolic acid
Scotch Broom
Sweet Clover
Stone Root
Terpenoids
Taxifolin
Troxerutin
Vincamine
Vitexin
Witch Hazel
Xantinol Nicotinate
Yumberry

Products containing Flavanones (various)

We currently have no products on Caring Sunshine that contain this ingredient.