Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Escin, a natural mixture of saponins extracted from horse chestnut seeds (Aesculus hippocastanum), is scientifically validated for supporting capillary health, particularly in the context of chronic venous insufficiency (CVI) and related vascular disorders. Multiple randomized, double-blind, placebo-controlled clinical trials and meta-analyses have demonstrated that escin can reduce symptoms such as leg swelling (edema), pain, and heaviness linked to capillary fragility and vascular insufficiency. The proposed mechanism is escin’s ability to improve venous tone, decrease capillary permeability, and exert anti-inflammatory effects, thereby enhancing microcirculation and capillary integrity.

A 2012 Cochrane review concluded that horse chestnut seed extract (standardized to escin) is more effective than placebo for short-term treatment of CVI symptoms. Additional studies have reported that escin reduces transcapillary filtration and strengthens capillary walls, helping to prevent leakage of fluid into surrounding tissues. The European Medicines Agency (EMA) also recognizes the traditional and well-established use of horse chestnut seed extracts for symptomatic relief of discomfort and heaviness of legs related to minor venous circulatory disturbances.

In summary, escin’s use for supporting the capillaries and vascular system is well-supported by scientific evidence, particularly for improving symptoms of venous insufficiency and reducing capillary permeability. However, most research pertains to chronic venous disorders rather than general capillary health in healthy populations.

More about escin
More about Capillaries

Other ingredients that support Capillaries

alpha-glycosyl isoquercitrin
anthocyanins
apple
astragalus
bilberry
black currant
blueberry
butcher's broom
Chinese salvia root
chokeberry
citrus bioflavonoids
fish oil
flavonols
garlic bulb
ginkgo biloba
gotu kola
grape
onion
hawthorn
hesperidin
horse chestnut
Japanese sophora
L-arginine
Nattokinase
orange
phenolic compounds
pine bark
quercetin
rutin
vitamin B
vitamin C
vitamin E
vitamin K
Water
capsicum
lingzhi
Yarrow
Yarrow
prickly ash
sodium salt
terpene lactones
polyphenols
purslane
shepherd's purse
herbal blend (proprietary)
cayenne pepper
ashitaba
asiaticoside
Aronia melanocarpa
Aescin
anthocyanidins
anthocyanosides
apocynin
astragalin
Baikal Skullcap
baicalein
benfotiamine
berry
bioflavonoids
coumarin
Centella triterpenes
cyanidin
Citrus
Centella asiatica
coca
capers
cypress
cranesbill
Collinsonia
Diosmin
danshen
delphinidin
dextran
diosmetin
epicatechin
Erigeron
eicosapentaenoic acid
escin
fruit
flavonoids
fatty acids
flavanones
Fagopyrum
flavoglycosides
flavans
flavonones
flavanols
flavones
Gypenoside
ginkgolides
ginkgo flavone glycoside
Ginkgoside
ginkgoheteroside
Hyperoside
Immortelle
linden
Ligustrazin
leucoanthocyanidins
Ligusticum
Mineral ascorbate
Oligomeric proanthocyanidins
Phenylpropanoids
pagoda tree
procyanidol
procyanidin
Pentacyclic triterpenoids
Phosphate ascorbate
Polydatin
proanthocyanidins
Periwinkle
punicalagins
Pycnogenol
polymethoxylated flavones
rue
Ruscus
Ruscogenins
Rutosides
Salmon Oil
Salvianolic acid
Scotch Broom
Sweet Clover
Stone Root
Terpenoids
Taxifolin
Troxerutin
Vincamine
Vitexin
Witch Hazel
Xantinol Nicotinate
Yumberry

Other body systems supported by escin

Arteries
Blood
Capillaries
Circulatory System
Joints
Lymphatics
Skin
Veins

Products containing escin

We currently have no products on Caring Sunshine that contain this ingredient.