Synopsis

Source of validity: Scientific
Rating (out of 5): 4

Diosmin is a naturally occurring flavonoid glycoside predominantly found in citrus fruits and is widely used to support vascular health, particularly for capillary and venous disorders. The primary scientific basis for its use comes from multiple clinical studies and meta-analyses that have evaluated its efficacy in treating chronic venous insufficiency (CVI), hemorrhoids, and related capillary fragility. Diosmin works by improving venous tone, reducing capillary permeability, and enhancing lymphatic drainage. Randomized controlled trials have demonstrated that micronized purified flavonoid fraction (MPFF), which includes diosmin (often paired with hesperidin), can significantly reduce symptoms such as leg swelling, pain, and heaviness in individuals with CVI.

The European Medicines Agency (EMA) and various vascular medicine guidelines recognize diosmin as an adjunctive therapy for venous disorders, citing moderate to strong evidence for its effectiveness. Its proposed mechanisms include protection of vascular endothelium, inhibition of inflammatory mediators, and enhancement of microcirculatory perfusion. While the bulk of the evidence supports its use for venous insufficiency and hemorrhoidal disease, which are closely related to capillary function, there is less direct evidence regarding isolated "capillary support" in healthy individuals. However, its actions on capillary permeability and resistance are well documented in pathologic contexts.

Overall, diosmin's use in supporting capillary and venous health is scientifically validated, with a substantial body of clinical evidence supporting its efficacy and safety profile in the context of vascular disorders.

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