Evidence supporting the use of: Citrus bioflavonoids
For the body system: Capillaries

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Citrus bioflavonoids are a group of plant compounds found in citrus fruits such as oranges, lemons, and grapefruits. They are often used in supplements to support capillary health. Scientific evidence suggests that certain bioflavonoids, particularly hesperidin and diosmin, can help strengthen capillary walls and improve microcirculation. Clinical studies have shown that these compounds can reduce capillary fragility and permeability, which is beneficial in conditions like chronic venous insufficiency, hemorrhoids, and varicose veins. The mechanism is thought to involve antioxidant activity, inhibition of inflammation, and stabilization of collagen in blood vessel walls.

However, while there is moderate scientific support for the use of specific citrus bioflavonoids in improving capillary function, the quality and size of the studies vary. Most evidence comes from research on isolated compounds rather than whole bioflavonoid mixtures as found in many supplements. The European Medicines Agency recognizes the use of certain bioflavonoids (e.g., diosmin) for venous disorders, but broad claims for all citrus bioflavonoids are not universally substantiated. Overall, the evidence base is respectable but not definitive, warranting a moderate rating.

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