Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bifidobacterium adolescentis is a probiotic bacterium that has been investigated for its potential to reduce side effects associated with cancer treatment, particularly chemotherapy and radiation-induced gastrointestinal toxicity. Preclinical studies in animal models have demonstrated that certain strains of B. adolescentis can help maintain gut barrier integrity, reduce inflammation, and modulate immune responses. In these studies, supplementation with B. adolescentis was sometimes associated with reduced severity of diarrhea and mucositis, common side effects of cancer therapy.

Human evidence, however, remains limited. Some small clinical trials and observational studies have included B. adolescentis as part of multi-strain probiotic formulations used to reduce gastrointestinal side effects in cancer patients. These studies have occasionally reported benefits such as decreased diarrhea and improved gut health, but B. adolescentis has rarely been studied in isolation, making it difficult to attribute effects specifically to this strain. There is also some emerging research into the role of B. adolescentis in modulating the efficacy of cancer immunotherapy, but findings are preliminary and not yet established for clinical use.

Overall, while there is a scientific rationale and some preclinical and limited clinical evidence suggesting a possible role for B. adolescentis in supporting gut health during cancer treatment, robust, high-quality human trials are lacking. The current evidence base supports cautious optimism but does not yet justify routine clinical use for this specific purpose.

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