Evidence supporting the use of: Vitamin D (ergocalciferol)
For the health condition: Calcium Deficiency

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Synopsis

Source of validity: Scientific
Rating (out of 5): 5

Vitamin D (ergocalciferol, or vitamin D2) is scientifically validated as a treatment and supportive therapy for calcium deficiency. Vitamin D plays a crucial role in calcium homeostasis by promoting intestinal absorption of calcium. Without sufficient vitamin D, dietary calcium absorption is significantly impaired, even if calcium intake is adequate. This effect has been well documented in both animal and human studies since the early 20th century.

Deficiency in vitamin D results in decreased calcium absorption, leading to hypocalcemia and consequent bone demineralization—manifesting as rickets in children and osteomalacia in adults. Numerous clinical trials have demonstrated that supplementation with vitamin D (either ergocalciferol or cholecalciferol) increases serum calcium levels and improves bone mineral density in individuals with vitamin D deficiency or calcium deficiency. Major clinical guidelines, including those from the Endocrine Society and Institute of Medicine, recommend vitamin D supplementation as an essential component in the prevention and treatment of calcium deficiency and related bone diseases.

Thus, the use of ergocalciferol to support or treat calcium deficiency is strongly supported by high-quality scientific evidence and is a standard of care in medical practice.

More about Vitamin D (ergocalciferol)
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