Evidence supporting the use of: Proteolytic enzyme (unspecified)
For the health condition: Bruises (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Proteolytic enzymes, such as bromelain (from pineapple) and trypsin, have been investigated for their role in supporting the healing and prevention of bruises. The rationale is that these enzymes may help break down fibrin and other proteins involved in inflammation and hematoma formation, thereby promoting the resorption of bruises and reducing associated swelling and pain. Several small clinical studies and meta-analyses, particularly with bromelain and combinations like trypsin-chymotrypsin, suggest modest benefits in reducing the severity and duration of bruising and edema following trauma or surgical procedures. However, the overall evidence base remains limited in size and methodological quality, with inconsistent results across studies. Most research focuses on post-injury or post-surgical settings rather than true prevention of bruising in healthy individuals. Furthermore, the "proteolytic enzyme" category is broad, and efficacy can vary depending on the specific enzyme and formulation used. While proteolytic enzymes are widely used in some countries and have some scientific support for their use in bruise management, robust, high-quality randomized controlled trials are lacking. Therefore, while the use is scientifically grounded to some extent, the overall strength of evidence is moderate at best and does not support widespread or definitive recommendations for bruise prevention in the general population.

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