Evidence supporting the use of: Flavonoids
For the health condition: Bruises (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Flavonoids, a diverse group of plant compounds found in fruits, vegetables, and certain supplements, have been studied for their potential role in supporting capillary health and reducing bruising. Scientific validation exists, primarily for specific flavonoids such as diosmin, hesperidin, and rutin. These compounds are thought to strengthen blood vessel walls, reduce capillary permeability, and exhibit anti-inflammatory properties, thereby potentially reducing the incidence and severity of bruises.

Clinical studies, particularly on the combination of diosmin and hesperidin (often used together in micronized purified flavonoid fraction, MPFF), have demonstrated efficacy in conditions related to capillary fragility and venous insufficiency. Some randomized controlled trials have shown that patients with chronic venous insufficiency or frequent bruising experienced fewer or less severe bruises when treated with flavonoid supplements. Additionally, flavonoids are used topically and orally in Europe for their vascular-protective effects, and several pharmacopeias recognize their use for capillary fragility and related symptoms.

However, while there is moderate scientific support (evidence rating: 3), the quality and quantity of studies specifically addressing bruising (as opposed to broader vascular conditions) are limited. More large-scale, high-quality clinical trials are needed for a definitive conclusion. Nonetheless, the available evidence supports the use of certain flavonoids as a reasonable adjunct in the prevention of bruises, especially in individuals with known capillary fragility.

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