Evidence supporting the use of: Citrus bioflavonoids
For the health condition: Bruises (prevention)

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Citrus bioflavonoids, often found in supplements alongside vitamin C, have been studied for their potential role in supporting capillary strength and reducing the tendency to bruise. The rationale behind their use stems from their biological activity as antioxidants and their purported ability to stabilize and strengthen blood vessel walls. Historically, flavonoids like rutin and hesperidin have been employed in European phytotherapy to address capillary fragility and related symptoms, including easy bruising.

From a scientific perspective, evidence supporting the use of citrus bioflavonoids for bruise prevention is modest but present. Some clinical studies, often small and sometimes not well-controlled, have shown that combinations of vitamin C with bioflavonoids can reduce capillary permeability and improve symptoms such as bruising and swelling. The mechanism is thought to involve enhancement of collagen synthesis and protection against oxidative damage to blood vessels.

However, rigorous, large-scale randomized controlled trials directly assessing citrus bioflavonoids for the prevention of bruises are lacking. Most evidence is either extrapolated from studies on capillary fragility or is anecdotal. Thus, while there is a plausible biological mechanism and some supportive data, the overall quality and quantity of evidence is limited, justifying a rating of 2. Citrus bioflavonoids may be helpful for some individuals, particularly those with mild capillary fragility, but should not be considered a primary or sole therapy for bruising disorders.

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