Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Chymotrypsin, a proteolytic enzyme derived from the pancreas, has a history of use in traditional and alternative medicine, particularly in some European and Asian countries, for the management and prevention of bruises and soft tissue injuries. The rationale behind its use stems from its ability to break down proteins, theoretically helping to reduce inflammation and facilitate the resorption of hematomas (bruises) by accelerating the degradation of damaged tissue and fibrin clots. Historically, oral and injectable preparations of chymotrypsin (sometimes in combination with other enzymes like trypsin and bromelain) have been recommended by practitioners to speed recovery from trauma, surgery, or sports injuries, and some clinical guidelines from the mid-20th century reference its use. However, while there are a few older studies and anecdotal reports suggesting moderate efficacy in reducing swelling and discomfort associated with bruising, the scientific evidence is limited and not robust by contemporary standards. Most clinical trials have small sample sizes, variable methodological quality, and often combine chymotrypsin with other enzymes, making it difficult to isolate its specific effect. Modern systematic reviews and guidelines do not widely endorse chymotrypsin for bruise prevention due to this lack of high-quality evidence. Therefore, its use for bruises is primarily justified by tradition and historical clinical practice, rather than strong scientific validation.

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