Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Shellfish exoskeletons are primarily composed of chitin, a natural polysaccharide, which can be processed into chitosan. In the context of supporting or treating broken bones, chitosan derived from shellfish exoskeletons has been explored in biomedical research as a component in bone graft substitutes, scaffolds, and wound healing materials. Several preclinical studies and some early-phase clinical research have investigated chitosan-based materials due to their biocompatibility, biodegradability, and ability to promote cell adhesion and proliferation. These properties make chitosan an attractive candidate for use in bone tissue engineering, where it can serve as a scaffold to support new bone growth. However, the clinical evidence supporting the widespread use of shellfish exoskeleton derivatives (like chitosan) for bone fracture healing is still limited. Most of the robust data come from animal studies or laboratory research, with only a few small-scale human trials. Chitosan is not a standard or first-line therapy for broken bones; rather, it is mainly investigated as a material to enhance healing or as part of composite grafts. There is no strong, large-scale clinical evidence yet to support its routine use in treating bone fractures in humans. Thus, while there is a scientific rationale and preliminary research, the current level of evidence remains modest.

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